Rapid deep hypothermia (suspended animation) is in clinical trials as an innovative new approach to emergency care when cardiopulmonary resuscitation (CPR) fails

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Emergency Preservation and Resuscitation (EPR), rapid deep hypothermia, is being pursued in clinical trials as a revolutionary approach to be the next standard of emergency care to save countless lives when CPR fails (CPR).

Approximately 2,000 people die each day in the US from traumatic exsanguination (bleeding) as a result of shootings, car accidents, or other serious traumatic injuries, and from other causes of cardiac arrest despite CPR. These numbers are alarming and cardiopulmonary resuscitation appears to be ineffective in most cases.

To reduce this tragic loss of life, EPR-Technologies is pursuing the development of an unprecedented standard of emergency care when CPR fails; that is, Emergency Preservation and Resuscitation. This innovative technology is geared towards providing hope of survival. The goal is to reduce the number of people who lose their lives during emergencies resulting from school shootings, sudden cardiac arrest, and vehicle accidents.

Speaking about the launch of EPR-Technologies, President and CEO Lyn Yaffe, MD, had this to say: “Rapid deep hypothermia has the potential to revolutionize resuscitation, providing one more chance to save a life when CPR fails, buying time for critical surgical and medical interventions, followed by delayed resuscitation and early recovery. EPR hopes to set a new standard for emergency medical care. As Dr. Peter Safar, MD (1924-2003), the father of the CPR and a pioneer in rapid and deep hypothermia, the goal is “saving hearts and brains too good to die. EPR-Technologies is dedicated to that goal.”

The FDA-approved EPR feasibility clinical trial is being conducted at the Maryland Shock Trauma Center in Baltimore, MD. Initially, the technology was developed to help save the lives of mortally wounded soldiers on the battlefield. The Army Medical Materials and Research Command has invested $17.5 million to date in cooperation with the University of Pittsburgh’s Safar Center for Resuscitation to develop the Emergency Preservation and Resuscitation procedure.

Originally, the EPR researchers used the term “suspended animation” to describe the impact of rapid and deep hypothermia in their early experiments, a term all too familiar in science fiction literature and movies. And like the current and preferable term “Emergency Preservation and Resuscitation,” suspended animation can be defined as a treatment to preserve the viability of the entire organism during ischemia or oxygen deprivation, such as during cardiac arrest. The objective of the first experiments in suspended animation, and now also valid for EPR, was to induce deep and rapid hypothermia.

Scientifically, RPE was designed to induce rapid profound hypothermia, a state in which oxygen supply is not required for more than 3 hours, thus buying vital time for transport to a hospital followed by surgical repairs and repairs. immediate medical interventions, followed by restoration of blood volume and delayed resuscitation, by extracorporeal circulation (ECC). EPR is the revolutionary next step in resuscitation to save the lives of loved ones too precious to lose.

“If it gets cold enough, it’ll be fine without blood for a while,” explained Samuel Tisherman, MD, professor of shock trauma surgery, Maryland shock trauma and EPR’s senior trauma surgeon. “We think we can buy time. We believe that it is better than anything else we have right now and that it could have a significant impact in saving many patients. It’s called Emergency Preservation and Resuscitation (EPR). It will be a game changer.”

EPR-Technologies has launched a crowdfunding campaign and investment opportunity for the public, businesses, and organizations seeking to make rapid deep hypothermia available in all life-saving trauma centers, hospitals, and emergency rooms. To invest in EPR-Technologies’ innovative technology before the crowdfunding campaign closes, visit


EPR-Technologies is a biomedical spin-off of the Safar Center for Resuscitation Research, University of Pittsburgh, and is committed to the preservation of human life through rapid and profound hypothermia through the introduction of patented products for Emergency Preservation and Resuscitation ( EPR) to save a life when it is standard. cardiopulmonary resuscitation (CPR) fails.

DotCom magazine names EPR-Technologies the Impact Company of the Year 2022.